Following a period close to fifteen years of fighting the extremist terrorist group Al Qaeda in Pakistan and Afghanistan, the United States (US) is faced with diverse security threats from affiliates of Al Qaeda in Africa. This study explores the extent of Al Qaeda's presence in Africa, security threat and policy implications to the US. A qualitative methodology through document analysis and informed by the interpretivist research paradigm was employed. With Al Qaeda's continued growth, there could be nuclear terrorism, arms and drug trafficking among other threats. Policy recommendations are given for the United States of America.