The state of the domestic economy and the level of implementation of modern technologies at the enterprises of the military-industrial complex make it problematic to fulfill all plans for the rearmament of the Armed Forces of Ukraine in a timely manner. Therefore, the most acceptable, both from a military and from an economic point of view, is the approach of situational integration of available forces and assets into target systems in a single information space by integrating reconnaissance, control and destruction assets. A reconnaissance and strike system, built of a multitude of subsystems united by information relations, which function as a whole, on the basis of uniform principles and rules, with agreed basic requirements for their components, which will increase the effectiveness of the combat use of troops due to a synergistic effect. Today, the integration of various forces and assets into target systems creates the preconditions for the existence of several possible variants of these systems, which have different assessments of the effectiveness of their use, the cost indicators of their creation, maintenance and use, as well as different time intervals for bringing them to combat readiness. Therefore, the system of indicators and criteria for evaluating and comparing various options for reconnaissance and strike systems or complexes, as well as existing approaches to justifying the choice of a rational option for these systems or complexes should have an integral criterion for choosing a priority option in the current situation. Therefore, the authors in the article proposed a general structure for constructing a methodological approach to a military-economic justification for the choice of a rational version of a reconnaissance-strike system or complex, taking into account military, economic and temporary factors that contribute to their creation, content and application, and also formed a complete structural and logical scheme of the proposed approach. In turn, the proposed methodological approach makes it possible to formulate basic recommendations on the procedure for its application in the headquarters, services of the Armed Forces of Ukraine in the formation of programs and plans for the development of weapons and military equipment of the Armed Forces of Ukraine and the Armed Forces of Ukraine as a whole.