Avian Influenza Virus Inactivation by Caprylic Acid, Sodium Caprylate, and Monocaprylin

Hariastuti, Nur Ika
Journal article Health Science Journal of Indonesia • April 2011

Abstract

Background: Avian influenza is an important viral disease caused by RNA viruses from the Orthomyxoviridae family. The virus is highly contagious, and transmission of the virus to humans resulted in fatal disease. Caprylic acid, a natural fatty acid, and its other chemical forms, namely sodium caprylate and monocaprylin, are highly effective in killing a variety of disease causing bacteria and viruses. This study was conducted to investigate the antiviral effect of caprylic acid, sodium caprylate and monocaprylin against avian influenza virus. Methods: Low pathogenic avian influenza viruses H5N1 and H5N2 were subjected to caprylic acid, sodium caprylate and monocaprylin. The reduction of viral particles in infected cells maintained in serial dilutions of caprylic acid, sodium caprylate, and monocaprylin and the positive controls were compared by using quantitative real-time RTPCR method. Results: Avian influenza viruses were inactivated by 0.2% and 0.4% caprylic acid up to 2 logs and 3 logs respectively. Sodium caprylate was not producing significant reduction of viral particles in this study. Whereas, monocaprylin has more effective doses to reduced the similar number of viral particles (0.08% - 2 logs and 0.16% - 3 logs). Conclusion: Low concentration of caprylic acid and monocaprylin in-vitro were able to reduce Avian influenza virus. Monocaprylin is more effective in reducing the viral particles compared to the other compounds. (Health Science Indones 2011; 2: 42 - 6)

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Health Science Journal of Indonesia

Health Science Journal of Indonesia is a journal published by the National Institute of Health Re... see more