An effort to reduce resistance, antibiotics prescription should be based on information about pattern of bacteria and  sensitivity to antibiotics. The aim of the study is to  determine the patternof bacteria, resistance and sensitivity to antibiotics at dr. Soedarso Hospital Pontianak 2011-2013. This research is a descriptive study with retrospective approach. Samples were culture and sensitivity test result in pus specimen of dr. Soedarso Hospital patient’s examined at ULK. Thenumber of samples in this study were 111 samples. There were 21 type of bacterias. Gram-negativebacterias were found more than gram-positive bacterias, 70.7% and 29.3%. Three of most frequentbacterias are Citrobacter freundii (18%), P. aeruginosa (17,1%) and Staphylococcus epidermidis(15,3%). Overall, the highest bacterial resistance is to metronidazole (96,4%), cephalexin (95,8%),cefuroxime (92,2%), oxacillin (91,7%) and cefadroxil (91,5%), and the highest bacterial sensitivityto piperacillin/tozobaktam (89,7%), meropenem (82,9%), imepenem (78,1%), amikacin (76,3%),fosfomycin/ trometamol (59,5%) and levofloxacin (56,1%).