Depression is a psychiatric disorder in the form of mood (i.e. affective or mood disorder), characterized by moodiness, lack of passion, feeling of uselessness and hopelessness. The prevalence of depressive disorder is 8-20% of the world population, with a higher prevalence in female than male. Treatment of depression is comprehensive and consists of pharmacologic therapy, somatic therapy, psychotherapy, psychoreligious theraphy and acupuncture. Recent research shows acupuncture can give antidepressant effect by increasing the release of serotonin and norepinephrine in the synaptic cleft. This paper reported a case of 65-year-old female patient who suffered from depression for eight years and had improved the hamilton rating scale for depression 17 (HAM-D 17) after acupuncture therapy.