Work stress is related to accidents, violence in the workplace, organizational strain in the form of absenteeism, decreased work performance, increased injury rates and employee turnover. Nurses are professionals who have high risks of occupational stress. The purpose of this study is to get the prevalens of work stress in nurses in Indonesia and the that influencing factors, using the instrument of ENSS Indonesian version. ENSS is an instrument of stress assessment specifically designed for nurses. ENSS has been adapted to the specific working conditions and culture of Indonesia. A total of 124 nurses were recruited, coming from hospitals and primary healthcare facilities. The higher the level of work stress experienced by nurses, the higher the value of measurement. No relationship was found between demographic characteristics and the level of stress in each subscale in both groups of respondents.