Background: Menstrual duration disorder may cause impaired work performance. The research objectivewas to identify risk factors related to menstrual duration disorder in female flight attendants.Methods: A cross-sectional study with convenient sampling was conducted on civilian female flightattendants age 19–50 years who underwent routine medical examination at Civil Aviation Medical Centerand Garuda Sentra Medika, Jakarta on May 18-29 2015. Menstrual duration disorder is menstruation morethan 8 days and/or shorter than usual perid (3-5 days). Stress was identified by usingcriteria of NationalInstitute for Occupational Safety and Health Generic Job Stress Questionnaire Mental Demands FormNumber 11. Relative risk was analyzed usng Cox regression.Results: Among 521 female civilian flight attendants, 393 were willing to participate in this study. Nineteensubjects were excluded, leaving 374 subjects for this analysis, and 35.8% of subjects had menstrualduration disorder. Job stress, flight type and age were dominant risk factors for menstrual duration disorder.Subjects with job stress and long haul flight within three months had higher risk for having menstrualduration disorder by 58% [adjusted relative risk (RRa) = 1.58; confidence interval (CI) = 0.96-2.62; P =0.071] and 69% (RRa = 1.69; CI = 1.17-2.43) respectively. Those between aged 30-39 years had 50% hadless risk of having menstrual duration disorder (RRa=0.50; 95% CI = 0.22-1.02; P = 0.057).Conclusion: Female civilian flight attendants with job stress, long haul flight within three months and youngerage had higher risk to be menstrual duration disorder. (Health Science Journal of Indonesia 2015;6:87-91)