Background: In Indonesia area of South East Nusa (SEN) and South Maluku are the area which is “semiringkai” of archipelago. The word 'semiringkai' means literally a state of archipelago with very dry climate approach that is somewhat less able to support the growth of vegetation. With the condition of the territory and influence of modernization at this point, it is necessary to know the disease burden in the region semiringkai community. Methods: A cross-sectional study design using data Riskesdas 2007 and 2013, to determine the prevalence of and changes in the burden of disease in Indonesia compared the people in NTT province. The calculation of DALYs loss (Disability Adjusted Life Year) is the summation of premature death (YLLs) and years lived with disability conditions (YLDs). Indonesia prediction of disease burden in 1990 and 2000 from IHME data used to support the description of the changes leading cause of death and burden of disease with associated risk faktors. Results: In 2010, six of the top ten causes of death cases due to non-communicable disease and DALYs loss of NCD cases tendency increased including road accidents. Overview of the proportion the disease burdens in the SEN semiringkai area the same or even higher than national picture, even worsened due the burden of infectious disease remains high (double burdens). Cardiovascular cases in SEN are predicted will continue to increase caused by the number of patients with hypertension (1 million), which exacerbated the high population (2.6 million) who consume cigarettes. Thereby triggering an increase in the number of deaths from cardiovascular disease. Conclusion: Control of health risk faktors for NCD cases is necessary as preventive measures and reduces the burden of disease in the territory of semiringkai, across sectors support is needed. Services of infectious diseases and improvement of contextual factors should also be further improved.