Ekspresi CTR1 Dan ATP7B Sebagai Prediktor Respons Kemoterapi Neoadjuvan Cisplatin Pada Kanker Serviks IIB

Putu Agus Suarta
Journal article Indonesian Journal of Cancer • June 2015 Indonesia

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(Bahasa Indonesia, 11 pages)

Abstract

The locally advanced cervical cancer is common in Indonesia and with limitation of radiation, chemotherapy is used as a neoadjuvant treatment. However the clear mechanism of accumulation chemotherapy in cervical cancer is still unclear. The purpose this study to determine CTR1 and ATP7B expression as a predictor of response to neoadjuvant chemotherapy cisplatin in cervical cancer IIB The design of this research is observational analytic form prospectively on 30 sample cervical cancer stage IIB. Before chemotherapy, Cervical biopsy was taken to evaluate expression CTR1 and ATP7B and MRI was done to measure the tumor volume. Furthermore, four cycles neoadjuvat chemotherapy (NAC) cisplatin 50mg/m2 every weeks. Two - three weeks after complete chemotherapy, repeated MRI examination. Assessment response to chemotherapy was catagorized by RECIST. Results: 30 samples obtained from the study of cervical cancer, before chemotherapy the smallest volume 23.35 cm3 and the greatest 276.23 cm3. After chemotherapy smallest 2.14 cm3 and largest 422.11 cm3. Chemotherapy response obtained Partial Response (PR) 23 (76.7%), Stable Disease (SD) 5 (16.6%), Progressive Disease (PD) 2 (6.7%). Relationship CTR 1 expression and response to chemotherapy according to RECIST obtained p value 0.002. Relationship ATP7B expression and chemotherapy response according to RECIST obtained with p value 0.009. In multiple logistic regression analysis obtained CTR 1 with p 0.006 and p value 0.454 ATP7B. Conclusions: CTR1 and ATP7B expression can be used as a predictor of response to chemotherapy neoadjuvant cisplatin in cervical cancer IIB, CTR expression more better as a predictor of response to neoadjuvant chemotherapy.

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Indonesian Journal of Cancer

The Indonesian Journal of Cancer (official journal of the Dharmais Cancer Center Hospital) is a p... see more