Basal Cell Carcinoma (BCC) is a Malignant neoplasm derived from nonkeratinizing cells that originate in the basal layer of the epidermis, which is locally invasive, aggressive, destructive, and rarely metastasize. BCC is more common in the elderly. Etiopathogenesis associated with BCC is genetic, environmental, and most often is exposure to ultraviolet light. Clinically, there are five types of BCC, which are nodular, superficial, morpheaform, pigmented, and fibroepitelioma Pinkus. Early detection of skin cancer can be done with self skin examination. Definitive diagnosis of Malignancy is determined by anatomical pathology examination. However, for very early BCC lesion, it's difficult to determine with hematoxylin eosin staining. Therefore, it is uses Ber-EP4 staining which is specific and highly sensitive for early BCC growing as budding in basal layer of the epidermis and follicles. This finding is particularly significant in the development of molecular pathology and clinical management of BCC lesions or suspected BCC.