There are 30-40% of people with allergies world wide in 2011, this is based on data from the Center for Disease Control and Prevention (CDC) more than tripled from 1993 to 2006. Parents play an important role in overcoming the recurrence of allergies in children in order of recurrence allergies and more severe recurrence. The goal of the study is to analyze association mothers's role and knowledge in recurrence prevention of food allergy in children under five years-old. The study is an analytic observational research with cross sectional design. Method of sampling usedis simple random sampling. The samples were 39 mothers who have children under five years-old with food allergy in Rumah Sakit Islam Jemursari Surabaya. Analysis used chi-square test with α = 0.05 significance level.The results revealed the knowledge of mothers' with allergy recurrance is 15 person (38,5%) have a good knowledge in prevention of food allergy in children under five years-old, while mothers's role in recurrence prevention of food allergy in children under five years-old is 26 person (66,7%) have a role unfavorable. The statistical test by using chi-square revealed there were association between mothers'role (ρ=0,030) and mother's of knowledge (ρ=0,00001)in recurrence prevention of food allergy for children under five years-old.The conclusions of the results this study is mothers's role with unfavorable to have children under five years-old with an allergy recurrence of severe allergy, while mothers with good knowledge to have children under five years-old with an allergy reccurrance of mild allergy.