: The research aims to analyze the different of region development in Gorontalo Province in the year 2008-2012, the development of region economy, and sectors that growth rapidly to be concerned in each region. The research uses the secondary data, namely, PDRB, and the growth of economy on each region. The tools use Williamson Index, Klassen Typology, Location Quotient (LQ), Model of Growth Ratio (MRP) and Overlay. Based on the analysis, we can conclude; the disparity of the region development is low with the value IW around 0,161-0,173. In Gorontalo Province, the region is divided into three quarters, namely, Boalemo and Bone Bolango in the 4th quarter (the low development, and low income), Gorontalo and Gorontalo Utara in 3rd quarter (high development, low income). Kota Gorontalo and Puhowato in 1st quarter (high development and high income). On each region in Gorontalo they have more than 2 sectors which growth so well.