West Sumatra province is one province in Indonesia which increased HIV and AIDS cases every year, and Bukittinggi is the case with the highest AIDS rate in West Sumatra. The purpose of research is to describe about the strategy that can be developed in response to hiv based on social and cultural approach. This study is a qualitative research. Data collection techniques through in-depth interviews with the HIV and AIDS risk group, and informants derived from the relevant agencies. Data processing and analysis were conducted qualitatively. The results showed that there are several steps that may be developed in an effort to combat HIV/AIDS approach that is based on an increase in social and cultural strategy information and community awareness of HIV/AIDS in a comprehensive manner, and institution strengthening community empowerment, improving the access of regulations coverage in and support the strengthed efforts to combat HIV/AIDS.