Schistosomiasis due to Schistosoma japonicum are still endemic in Indonesia, especially in Lindu, Sigi Regency, Napu and Bada Plateu, Poso Regency, Central Sulawesi. The proportion of co-infection soil transmitted helminths and schistosomiasis information in the endemic areas is still limited. The aim of this study was to determine the proportion of co-infection between schistosomiasis and soil transmitted helminth. The information was obtained from the stool survey conducted by Schistosomiasis Control Programme, Provincial Health Office Central Sulawesi, from January to June 2013 in North Lore and East Lore District, Poso Regency. Stool samples were examined with Kato Katz technique. The result shows in North Lore, Schistosoma japonicum infection was 1.62 %. Co-infection of Schistosoma japonicum and Ascaris was 0.25 %, S. japonicum and Hook worm 0.18%, and also S. japonicum and Trichuris trichiura 0.06%. In East Lore, the prevalence of Schistosoma japonicum was 3.00 %. Co-infection of S. japonicum and Ascaris 0.82 %, S. japonicum and Hookworm 0.37%, S. japonicum and Trichuris trichiura 0.22%. The proportion of soil transmitted helminths and Schistosoma japonicum was high in the location.