Chronic Obstructive Pulmonary Disease (COPD) is a disease that become the tenth on top ten global burden of disease, and also the tenth as the non-communicable disease's cause of death on hospital inpatient. Muara Enim, is one of the districts in the South Sumatra Province which has the largest coal mine in Indonesia, located in the sub-district of Tanjung Enim. There are variety of adverse effects caused by the dredging of coal in the mining area in Muara Enim, including the occurrence of COPD. The study design was cross-sectional. The sample was 469 individual sample in household in the designated area and 504 in the non-designated area. The aim of this study was to describe COPD in the district of Muara Enim, South Sumatra Province. The results shown that the symptoms based cases of COPD is higher in the designated area (1,07%) rather than non-designated area (0,20%), as well as symptoms/diagnosed is higher in the designated area (2,35%). Outdoor and indoor air quality based on the average value of S02, NO2 and PM10 was higher on the designated area, and the habit of smoking more than 1 month is higher in designated area (35,8%). In conclusion, based on the symptoms and the symptoms/diagnosed, the COPD prevalence was higher in the designated area than non-designated area.