The objective of the analysis is to determine the factors that associated with Down Syndrome (DS), Cerebral Palsy (CP) and other disabilities (blind, deaf, speech impaired, physically disabled, ormentally disabled). The data that used in this analysis were from Basic National Health Survey (Riskesdas) 2010. Subjects were children aged 24-59 months and their birth mother (11.115 children). Nine defect children had been found from West Java Province in 2010 were verified by visiting to their home. In Indonesia, the prevalence of DS, CP and other defects were respectively 0,07%; 0,05%; and 0,39%. Mothers who gave birth above 35 years old have risk of having a DS child 4,8 times (CI: 1,225 to 20,265; p=0,034) than mothers who gave birth at and below 35 years old. Mothers who live in a slum area have risk of having other defect children 2,1 times(CI: 1,225 to 4,109; p=0,021) than mothers who not live in slum area. Maternal age at delivery is associated with DS. Living environment is associated with other defects. Counseling to pregnant women aged ≥ 35 years old and living in a rundown neighborhood in order to antenal care every month so that the incidence of DS and other defects can be prevented.