In last three years, Malaria cases in District Kabola was fluctuating. There was 414 Malaria cases in 2011, decreased into 107 in 2012, and increased into 327 in 2013. The aim of this study is to determine the relationship of people's behavior, socio-economic factors and the use of netting with the incidence of malaria in Kabola Village. This is an analytical research with cross - sectional design and 180 people were taken as a sample of 327 people. This research use probability sampling with Stratified Random Sampling method. Result showed that there is a relationship between education (p = 0,017), income (p = 0,007), knowledge (p = 0,016), attitude (p = 0,000), action (p = 0,012), and the use of mosquito nets (p = 0,021) with Malaria incidence. Meanwhile, occupation (p = 0,063) has nothing to do with Malaria incidence. In conclusion, Malaria incidence has relationship with education, income, knowledge, attitudes, actions, and the use of mosquito nets, while occupation has nothing to do with malaria incidence. It is recommended that health care providers (health centers, Pustu, Polindes, and Posyandu) have to give more information/ counseling about prevention, eradication, and malaria handling.