: Efforts Regional Government in Local Economic Development Through Empowerment of Small and Medium Industries (Studies in the Dinas Perindustrian Perdagangan dan Pasar Kabupaten Jombang and Sentra Industri Kerajinan Cor Kuningan Desa Mojotrisno Kecamatan Mojoagung Kabupaten Jombang). The Buffer economy Jombang one of which is the industrial sector. The development of industrial sector Jombang still experiencing problems including that occurs in the sentra industri kerajinan cor kuningan, so it needs the efforts of the Dinas Perindustrian Perdagangan dan Pasar (Disperindagpas) in overcoming these obstacles. The results showed that the efforts of Disperindagpas which include: human resource development, marketing of handicraft products of cast brass, and facilitation of access to capital. The result of the efforts of Disperindagpas can provide expansion of employment opportunities and strive, expansion of income generation, empowerment of cast brass handicraft industry center in the process of production and marketing, institutional empowerment of the working relations between the government and employers craft of cor kuningan.