. A cross sectional study on the incidence and the risk factors of green tobacco sickness wascarried out inBansari village, Sindoro mountain range, Parakan sub district,Temanggung District, CentralJava.The subject of the study consisted of 80 of tobacco-leaf pickers, who were healthy,without hypertension, tachycardia, and hyperpnoea story. Data were collected through interview, physicalexamination(blood pressure, pulse, frequency of breath), and Cotinineurine examination (competitiveimmunoassaymethod with Coti Traq-Serex).Data were analyzed using SPSS program. The incidence ofGTS was found about 64%. The symptoms were found frequently including dizzy, headache, and fatigue.Therisk factors that influence GTS were working experience, location of the leaf, and the use of safetyprotector.Statistical analysis showed that the incidence of GTS among pickers who had long workingexperience,middle location of the leaf, and wore long-sleeve shirts was significantly lower than pickerswhohad short working experience, middle-high location of the leaf, and did not wear long-sleeve shirts.