The objective of research is to explain the influence of Corporate Social Responsibility (CSR) on company profitability as represented by Return On Asset (ROA), Return on Equity (ROE), and Earning Per Share (EPS). Research type is explanatory research with quantitative approach. The population of research is 33 companies registered within SRI-KEHATI Index which lists on Indonesia Stock Exchange in period 2010-2012. Sample is 14 companies. Sampling method is purposive sampling. Analysis technique is simple linear regression. In the practice, statistic test is preceded by classical assumption test. Result of research indicates that CSR has significant influence on ROA and ROE, but CSR it does not have significant influence on EPS.