Mudharabah and Musyarakah were few types of financing methods that distribute funds to help Mudharib actors to develop their own startup but under compliance with certain conditions and profit-share agreements. Profit-share of the startup was given to capital owner (Shahibul Maal) and capital receiver (Mudharib), or could be extended to other participants in business management. The higher was the financing provided, the more bank profitability was increasing. This research was aimed to understand the effect of profit-share financing methods of Mudharabah and Musyarakah simultaneously and partially on profitability by using Return on Equity (ROE) as profitability indicator. Method of research was explanatory with quantitative approach. Population of research included 11 Syariah Commerical Banks listing with Indonesia Stock Exchange in Period 2011-2014. However, only 4 Syariah Commercial Banks in research population were taken as sample using purposive sampling. Analysis technique in this research was multiple linear regression. Result of research indicated that profit-share financing methods of Mudharabah and Musyarakah were simultaneously positively influential to profitability (ROE). Partially, result of research had shown that Mudharabah profit-share financing method was giving positively and significantly effect on profitability (ROE), whereas Musyarakah profit-share financing method was bringing negatively but significantly effect on profitability (ROE).