Research aims to acknowldge the financial performance of PT Indofood Sukses Makmur, Tbk and Subsidiaries during 2010-2014 period using Du Pont System modified. This analysis is one of the techniques of financial performance analysis are developing analyzes of Du Pont System by adding Equity Multiplier or Debt Ratio and connect with ROI to determine ROE. This research use descriptive research with quantitative approach, the source of the data used is secondary data with data collection documentation. Based on the research results can be concluded that financial performance of PT Indofood Sukses Makmur, Tbk and subsidiaries in 2010-2014 were analyzed using Du Pont System Modified be in poor condition. That is because ROE decreased. The decline was due todeclining ROI and Equity Multiplier ride. ROI is declining due to the state of NPM is likely to decline and TATO fluctuating. Increased Equity Multiplier caused by total assets and total equity increased. Companies should improve efficiency in the use of equity capital as well as asset management and increasing sales greater than the costs of operations. Additionally, Equity Multiplier which increase indicates that more companies use debt to finance its assets, so the company should be able empower debt.