The aim of this study was to determine the effect of macro-economic conditions which including the exchange rate, BI rate, inflation and economic growth of the composite stock price index.Stock was one of investment in the capital market the most attractive to investors.This study had used explanatory research with quantitative approach. Determination of the sample was based on time series data quarterly period July 2005 – June 2015 by using saturation sampling method, which resulted 40 as number of samples. This study also had chosen multiple linear regression as attempts to analyze data. The simultaneous test (F test) resulted that the exchange rate, BI rate, inflation and economic growth simultaneously had given significant effect on the stock price index. Meanwhile, the partial test (t test) had indicated that the exchange rate variable and BI rate significantly influenced the stock price index. In contrast, rate of inflation and economic growth had not showed significant effect on the stock price index. The conclusion based on this research was stock investors should be more considerate on the economic conditions such as covering the exchange rate, BI rate, inflation and economic growth before finalized their investment decisions in order to reach the maximum benefit.