This study will explain how cultural barrier, cross-cultural communication and employee job stress occur at PT. Krakatau Daedong Machinery. The study also aimed to determine whether there is a significant relationship between the cultural barrier, cross-cultural communication and employee job stress . This research located at PT. Krakatau Daedong Machinery - Cilegon with all the employees and staff as a population. Explanatory research was conducted in this research with a quantitative approach. In this study cultural barrier consist with language differences, ethnocentrism, and behavior differences as exogenous variable, meanwhile cross-cultural communication and employee job stress becomes an endogenous variable in this study. Data collection techniques in this research is by questionnaires that is completed by employees as respondents. The analyisis data method in this study will be using descriptive analysis and path analysis method.