: This study was based on the individual and social constuctivist learning theory. This study was aimed to examine the effectiveness of the collaborative learning and traditional individual learning to improve the students' problem solving skills. This study used the quasi-experimental design. The subjects were 60 Chemistry students enrolling the Chemistry Mathematics course. The findings showed that the effectiveness of both methods was influenced by the type of the chemistry materials being studied and relevant mathematical concepts. The problem solving skills of the students learning individually was better than those of the students learning collaboratively in the kinetics concept using the calculus concept. However, both learning settings gave the same influence on the chemistry problem solving skills using the basic mathematics concepts such as logarithma and algebra. In addition to the learning approach, the students' problem solving skills were also influenced by several factors including: cognitive and learning experience factors, These findings can give contribution to the choice of learning strategies by taking into account of the influential factors.