This research aims to identify and explain the effect of partially and simultaneously job stress of nurses labour conflict of nurses, and social support of nurses to job satisfaction of nurses at the HVA Toeloengredjo Hospital .The kind of this research is explanatory research and by using non probability sample. Data collection by distributing questionnaire to 70 nurses as respondents ofHandles Vereneging Amsterdam (HVA) Toeloengredjo Hospital. Data analysis in this research used descriptive statistical analysis and using multiple linear regression analysis by SPSS Program v 21.0.0 Result of multiple linier regression that simultaneously and partially variable of job stress of nurses and labor conflictof nurses and social supportof nurses have significant influence on satisfaction of nurse. It is supported by result of simultaneous test indicates that F-significance 0,000 < 0,05. The regression coefficient obtained in this study of 0,551 which means that the variable of job stress of nurses, labor conflictof nurses and social supportof nurses have influence of 55,1% towards job satisfaction of nurses, while the remaining 44,9% are effected by other variable unobserved in this research.