This study was planned to last for two years which is a collaboration of survey research and experimentation. As a preliminary step, specific objectives of this study are as follows. (1) to analyze the level of technical efficiency tilapia nursery business, and (2) to analyze the degree of allocative efficiency and economical efficiency of tilapia nursery business. The study population was the tilapia nursery businesses, amounting to 136 people. Sampling using census method. The efficiency of utilization of production factors is analyzed using a production function approach Cobb-Douglas type.The results showed that (1) the technical efficiency is relatively low tilapia nursery that ditunjuukan by technical coefficients of Cobb-Douglas production function of 1.45; and (2) separating tilapia in the village Sanding inefficient both in terms of allocative and economical. Based on these results, it is suggested that the use of factors of production of fish seed, feed, and a spacious pool needs to be reduced proportionately namely, fish seed into 3 kg to 60 kg of feed, and a spacious pool to 75 m2.