Exsanguination is the primary cause of death in trauma. The mortality can be prevented if bleeding can be stopped and blood loss can be replaced with fluid. Fluid resuscitation has been proven to improve tissue perfusion and reverse the cellular injury and swelling in state of hemorrhage. Fluid resuscitation can also depress the cytokines that could lead to multiple organ failure in hemorrhagic shock. The method of fluid resuscitation widely used nowadays refers to guideline by American College of Surgeon. Despite its wide application, some studies reported the guideline may be harmful and addressed the lack of its scientific basis. These studies introduced another strategy called small volume fluid resuscitation. Although studies were limited to animal model and some small clinical trials, they showed promising result for small volume fluid resuscitation. Small volume fluid resuscitation could reduce the additional blood loss due to continued bleeding or re-bleeding and lower mortality rate. Small volume fluid is an appropriate option in resuscitating patients especially those with uncontrolled hemorrhage.