Introduction.Tuberculous spondylitis is a devastating health problem in Indonesia. The goal of treatment is to relieve pain, so the patients can do their daily activities. The instrument used to assess quality of life and perceived pain scale is Short Form-36 and visual analogue scale. The objective of this study is to comprehend the changes in quality of life and pain scale in tuberculous spondylitis patients before and after surgery. Materials and methods. Forty five patients with tuberculous spondylitis in Cipto Mangunkusumo Hospital were asked to fill Short Form-36 and visual analog scale before and after surgery. The data was analyzed and compared before and after surgery in 8 aspects, which is physical function, physical health, bodily pain, general health, vitality, social function, emotional problems, and mental health.Results.Surgery significantly improved patients' quality of life in all aspects with average physical component summary from 23 to 70 and mental component summary from 35 to 75 (p < 0.001). There was significant decrease in visual analog scale from seven to one. Significant correlations were seen between American Spinal Injury Association status and physical component summary, between American Spinal Injury Association status and mental component summary after surgery (r = 0.46 and r = 0.48). We categorized the patients into three groups based on duration follow up. There was increased physical component summary and mental component summary for each group. Increased quality of life was shown by improvement of Short Form-36 score. VAS score decreased significantly in post-operative group.Conclusions.Fusion and posterior instrumentation surgery improves patient's quality of life and decrease the perceived pain scale.