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description Journal article public Indonesian Journal of Orthopaedics

The Effect of Desferoxamine on Bone Healing of Tibial Fracture with 2 Mm Defect in Sprague Dawley Rat

Fitri Agus Santy, Ismail Hadiesoebroto Dilogo
Published August 2012

Abstract

Introduction.Desferoxamine is one of iron chelating drugs. With the chelation of iron, phosphatidylinositol -3- kinase inhibitor is inhibited so that the release of endothelial nitric oxide synthesis phosphorylation is uninhibited. We examined whether addition of desferoxamine would lead to fracture healing enhancement. Material and methods. Twenty four Spargue Dawley mice were used in the study. Their tibias were fractured and 2 mm defect were created. The fractures were then fixated using intramedullary K-wire. They were then allocated into four groups: group I received nothing, group II, III, and IV received desferoxamine since the first, fifteenth, and twenty second day respectively. The radiological and histological scores were measured at the sixth week and analyzed using ANOVA test.Results.There were significant differences in radiological and histological scores among groups. (p = 0.024 and p = 0.007 respectively)Conclusions.Addition of desferoxamine since the fifteenth but not after the twenty second days enhanced fracture healing.

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