Introduction.Chronic wounds are very common and difficult to treat. One of recent methods is the application of hydrogel polyurethane foam. This study aims to compare hydrogel polyurethane foam with saline wet gauze, in the healing process of chronic ischemic wounds in rabbits.Materials and methods.Ischemic chronic wounds were made to the cartilage in the left ear of 16 male rabbits. Wounds were treated with hydrogel polyurethane foam and saline wet gauze for 4 weeks.Results.Chronic wounds heal with the use of hydrogel polyurethane foam in 15 samples (93.75%). While using saline wet gauze, chronic wounds heal in 13 samples (81.25 %). Conclusions. Application of hydrogel polyurethane foam has clinically better result than saline wet gauze although there is not any statistically significant difference.