United States is state which gives impact on cooperation with ASEAN (Association of Southeast Asia Nations). It's foreign policy influence International rezime. The direction of United States foreign policy which is determined by chosen President also influence ASEAN region in which most of the member states are potential for International market. Indonesia, Malaysia, Singapore, or The Philipines are examples which are influenced by Unites States's foreign policy. In the Donald Trump rezime, it is hard to predict United States's foreign policy. It becomes a challenge for ASEAN member countries which still reckon on investment and cooperation with developed states like United States. Alliance with the United States under rezime of Donald Trump and its foreign policy in the security and economy is hard to be predict, which then influence ASEAN advancement as a regional organization. This research is aim to analyze United States's foreign policy under rezime of Donald Trump and correlate it with cooperation between Unites States-ASEAN.