. This study aimed to discuss the Semiotics in the Quran, foccused in: 1) the concept of semiotic significance in the study of the Quran; 2) the history of the application of semiotics on scripture; 3) the characteristics of the Qurani's semiotics. This research is a literature research (library research), that is the research conducted research of various literature related to the problem under study. The results of this study indicate that: 1) Semiotic approach in the Quran contains a meaning that is an attempt to study and interpret the Quran with the workings and functions of signs in the text of the Quran as the orientation of the study; 2) Saint Augustinus is the first founder of the sign system in the study of the Bible; 3) the characteristics of semiotics in the Quran contains the concept of ma'rifah and nakirah, the addition of letters has implications for the change of meaning; one word has many meanings. The implication of this research is that a Muslim, especially Muslim academic, is always eager to learn the Quran. Because the success of a Muslim in expressing semiotics in the Quran have a positive impact for success in the world and in the afterlife.