This study aimed to examine the curriculum at the senior secondary school related to nuclear science and technology in content standards, textbooks, teaching methods, and teacher understanding. Locations determined by purposive sampling in six provinces namely Yogyakarta, East Java, West Nusa Tenggara, East Kalimantan, Riau Islands, and South Sulawesi. The respondent are a teachers of Biology, Physics, and Chemistry respectively 18 people in each province. The research method is a survey and focus group discussion. The study shows that nuclear science content standards are adequate, but the application of nuclear science and technology of today need to be added. Textbooks used is more theory and less contextual of life. Nuclear science and technology learning in general lectures, discussions and giving assignments. Teachers' understanding of the concepts and applications of nuclear science and technology is still low. The study recommends the present applications of nuclear science and technology need to be added to the content standards, schools need to socialize to the understanding of nuclear science and technology is better, should be made in the book supplements or media-based learning model using information and communication technology to support learning of nuclear science and technology for effective, efficient, and fun learning.